Endocrine Abstracts

Aim: To find if testosterone undecanoat 1000 mg injection (Nebido; Bayer-Schering) has a negative effect on prostate.Materials and methods: i) PSA (ng/ml) was registred retrospective (from files) and prospective analysis (onset 2010). ii) From over 175 patients to whom testosterone undecanoate 1000 mg, i.m. was administrated at 3 months, in the last 4 years, and to whom the prostatic volume was quantified (Journal of Sexual Medicine8</st...

The aim of the study was to assess lipid status in subjects with hypothyroidism (overt and subclinical) and hyperthyroidism. Therefore, we analyzed the relationship between the levels of blood lipids (Lp(a), Apo AI, Apo B, Apo AI/B, total cholesterol (TC), triglyceride (TG), LDL, HDL, LDL) and TSH, FT4, T3, TPOAb concentration. The study groups included 38 subjects with overt hypothyroidism (mean±S.E.M., age 48.6±13.25 years), 30 ...

Graves’ thyrotoxicosis frequently occurs after delivery through immune rebound mechanism. A 34 years old patient, in postpartum period was referred to rheumatologist for gradually gait impairment. Examination showed only weakness of pelvic girdle muscles which required an extensive differential diagnosis including: neurological diseases and inflammatory/metabolic/toxic myopathies. Routine lab tests were unremarkable except low cholesterol (128 mg/dl) and slightly increase...

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

Background: Recurrenthyperparathyroidism following total parathyroidectomy with autotransplantation in patients with end-stage renal disease who are on hemodialysis is not an uncommon condition and can be due to hyperplastic autografted tissue, remnant parathyroid tissues in the neck or in the presence of ectopic and/or supernumerary parathyroid glands.Case report: We report the case of a 66-year-old patient with a history of chronic kidney disease on he...

Intentional insulin overdose in diabetic patients is a rare critical situation. The severity is due to numerous neurological complications, electrolyte disturbances, liver and lung damage or death. A 59-year old female, under treatment for depressive disorder, diagnosed with type 2 diabetes since 2016 and treated with glargine (20 IU/day), lispro (30 IU/day) insulin and Metformin (500 mg/day) was admitted to the Internal Medicine department via ER (emergency room) for repetiti...

Cutaneous lymphoid hyperplasia (CLH) is a spectrum of benign conditions characterized by reactive B- and T-cell cutaneous lymphocytic infiltrates. The most common presentation of reactive CLH is as a solitary red skin papule, nodule, or plaque but 10–15% of patients present with more generalized or multifocal skin lesions. A 40-year old male, initially diagnosed with type 1 diabetes mellitus (DM), with a family history of autoimmune thyroid disease, vitiligo and type 2 DM...

Introduction: Nijmegen breakage syndrome(NBS) represents a rare autosomal recesive disorder, characterized by severe chromosomal instability. It is caused by mutations in the NBN gene, which product, nibrin, belongs to the hMre11/hRad50 protein complex, critical for processing DNA double-strand breaks during mitotic and meiotic recombination. The hallmarks of NBS are growth retardation, microcephaly, premature ovarian failure(POI) in females, immunodeficiency and predispositio...

Introduction: Thyrotropin-secreting pituitary tumors (TSH-omas) are a rare disorder and an infrequent cause of hyperthyroidism. The prevalence in the general population being 1 to 2 cases per million. However, recents studies have demonstrated an increase of TSH-omas over time. The increased number of cases principally results from the ultrasensitive TSH immunometric assays and from improved general practioner endocrinologist awaress. There is an inappropriate secretion of TSH...

Background: Association of differentiated thyroid carcinoma (DTC) and cortisol-producing adrenal adenoma is not part of the classical MEN syndromes. We present a clinical case raising the question of a common etiology for these tumours.Case Presentation: A 58-year-old female presented in 2010 for the investigation of a 6 cm left adrenal tumour incidentally discovered by abdominal CT. Medical history included smoking, obesity, myocardial infarction, hyper...